COMPARATIVE STUDY OF EFFICIENCY AND SAFETY OF THE NEW DRUG OF AMLODOPINE – S-AMLODOPINE IN PATIENTS WITH ARTERIAL HYPERTENSION OF I-II DEGREE

Abstract

Aim. To evaluate efficacy and safety of a new drug of amlodipine – S-amlodipine (Azomex, Emcur, India) compared to original drug of racemic amlodipine (Norvasc, Pfizer, USA) in patients with arterial hypertension (HT) of I-II grade.Material and methods. 39 patients with HT of I-II grade were randomized into two groups and took drugs of amlodipine during 8 weeks. Ambulatory blood pressure monitoring (ABPM) was undertaken before treatment and at the end of treatment.Results. 34 patients completed 8-week therapy. Both drugs showed antihypertensive effect: significant decrease in average levels of systolic and diastolic blood pressure (BP) recorded by office and ABPM measurements. Compared to racemic amlodipine S-amlodipine caused bigger decrease in systolic and diastolic BP and bigger decrease in daily and 24-hour average diastolic BP after 4 week of therapy.Conclusion. S-amlodipine is effective antihypertensive drug, showing more significant BP decrease in comparison with this of racemic amlodipine after 4 weeks of treatment.

Keywords

• arterial hypertension
• ambulatory blood pressure monitoring
• s-amlodipine
• racemic amlodipine