Features of functional annotation of rheumatoid arthritis susceptibility genes by Cytoscape

Abstract

Aim. To evaluate the functional annotation of genes associated with rheumatoid arthritis with different parameters of the ClueGO Cytoscape tool.Materials and methods. Genes of susceptibility to rheumatoid arthritis were extracted from publicly available database GWAS (catalog of associations of single nucleotide polymorphisms with diseases). The Gene Ontology (GO), the functional annotation of genes, was performed using Cytoscape ClueGO. The features of the functional annotation using the plugin ClueGO Cytoscape were analyzed. Results. Depending on the initial parameters specified in the plugin, the grouping of terms according to the gene ontology was carried out with a different degree of generalization. A smaller minimum number of genes in a group allows to form a larger number of groups, which makes it possible to obtain more detailed functional characteristics.Conclusion. The results obtained with different grouping options can be useful for further studies of genetic mechanisms of rheumatoid arthritis.

Keywords

• функциональная аннотация генов
• ревматоидный артрит
• gwas
• cytoscape