Frontiers in Immunology (Apr 2023)

CCL13 and human diseases

  • Laifu Li,
  • Laifu Li,
  • Fei Dai,
  • Fei Dai,
  • Lianli Wang,
  • Lianli Wang,
  • Yating Sun,
  • Yating Sun,
  • Lin Mei,
  • Lin Mei,
  • Yan Ran,
  • Yan Ran,
  • Fangchen Ye,
  • Fangchen Ye

DOI
https://doi.org/10.3389/fimmu.2023.1176639
Journal volume & issue
Vol. 14

Abstract

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CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many immune cells. Despite extensive research into its function in numerous disorders, a thorough analysis of CCL13 is not yet accessible. The role of CCL13 in human disorders and existing CCL13-focused therapies are outlined in this study. The function of CCL13 in rheumatic diseases, skin conditions, and cancer is comparatively well-established, and some studies also suggest that it may be involved in ocular disorders, orthopedic conditions, nasal polyps, and obesity. We also give an overview of research that found very little evidence of CCL13 in HIV, nephritis, and multiple sclerosis. Even though CCL13-mediated inflammation is frequently linked to disease pathogenesis, it’s fascinating to note that in some conditions, like primary biliary cholangitis (PBC) and suicide, it might even act as a preventative measure.

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