A molecular quantitative trait locus map for osteoarthritis

Julia Steinberg; Lorraine Southam; Theodoros I. Roumeliotis; Matthew J. Clark; Raveen L. Jayasuriya; Diane Swift; Karan M. Shah; Natalie C. Butterfield; Roger A. Brooks; Andrew W. McCaskie; J. H. Duncan Bassett; Graham R. Williams; Jyoti S. Choudhary; J. Mark Wilkinson; Eleftheria Zeggini

doi:10.1038/s41467-021-21593-7

Nature Communications (Feb 2021)

A molecular quantitative trait locus map for osteoarthritis

Julia Steinberg,
Lorraine Southam,
Theodoros I. Roumeliotis,
Matthew J. Clark,
Raveen L. Jayasuriya,
Diane Swift,
Karan M. Shah,
Natalie C. Butterfield,
Roger A. Brooks,
Andrew W. McCaskie,
J. H. Duncan Bassett,
Graham R. Williams,
Jyoti S. Choudhary,
J. Mark Wilkinson,
Eleftheria Zeggini

Affiliations

Julia Steinberg: Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
Lorraine Southam: Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health
Theodoros I. Roumeliotis: Wellcome Sanger Institute
Matthew J. Clark: Department of Oncology and Metabolism, University of Sheffield
Raveen L. Jayasuriya: Department of Oncology and Metabolism, University of Sheffield
Diane Swift: Department of Oncology and Metabolism, University of Sheffield
Karan M. Shah: Department of Oncology and Metabolism, University of Sheffield
Natalie C. Butterfield: Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
Roger A. Brooks: Division of Trauma & Orthopaedic Surgery, Department of Surgery, University of Cambridge
Andrew W. McCaskie: Division of Trauma & Orthopaedic Surgery, Department of Surgery, University of Cambridge
J. H. Duncan Bassett: Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
Graham R. Williams: Molecular Endocrinology Laboratory, Department of Metabolism, Digestion and Reproduction, Imperial College London
Jyoti S. Choudhary: Wellcome Sanger Institute
J. Mark Wilkinson: Department of Oncology and Metabolism, University of Sheffield
Eleftheria Zeggini: Institute of Translational Genomics, Helmholtz Zentrum München – German Research Center for Environmental Health

DOI: https://doi.org/10.1038/s41467-021-21593-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

Read online

Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthritis patients to pinpoint genes of action and potential drug treatments.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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