Advances in Biomedical and Health Sciences (Jul 2024)
A holistic cure for cancer and survival from the indirect effects of nuclear attack
Abstract
Background: The global search for a safe, irreversible cure after lethal radiation exposure and cancer has not been successful since World War II. Nuclear warfare cannot be recreated in a laboratory. Simulation experiments require highly classified, expensive, and approved infrastructure. Chemotherapy and radiotherapy affect both healthy and damaged cells and often lead to cancer recurrence. A lethal dose of ionizing radiation (IR) is devastating because of instant, massive, and diffuse DNA breaks, chromosomal aberrations, tissue oxidation, and the cascading generation of free radicals, and it can cause cancer. People exposed to a nuclear attack directly cannot be cured. Methods: A formulation comprising aqueous extracts of leaves of Indian bael (Aegle marmelos) and Oxalis corniculate, roots of ginseng (Panax ginseng), custard apple (Annona squamosa) or sitaphal cotyledons, methi (Fenugreek) seeds, and lytic Newcastle disease virus (nonhuman) was used. A few doses of the formulation were injected intraperitoneally into lethally gamma-irradiated mice; mice were also injected with Ehrlich ascites carcinoma cells. Breast and cervical cancer cells were treated with this formulation in vitro. Results: We have developed a solution to the lasting problem. The formulation induced apoptosis in IR-damaged cancer cells by the developed formulation in vivo and in vitro, with no subsequent regrowth. No adverse effects were observed. The control ‘DF1’ Fibroblast cells did not exhibit any change after the drug administration. A possible explanation is the loss of defense responses in damaged cells, allowing the multiplication of the killer virus. Thus, people with cancer and those who escape the direct impacts of nuclear accidents may be saved. The lyophilized components can be stored at room temperature under field conditions. Conclusion: Successful treatment with herbs and virotherapy (a nanomedicine) can be delivered as tablets (a stable formulation) to remote areas, which may be a permanent solution to the prolonged search for the treatment of radiation exposure.
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