EBioMedicine (Dec 2024)
Bivalent Omicron BA.1 vaccine booster increases memory B cell breadth and neutralising antibodies against emerging SARS-CoV-2 variantsResearch in context
- Lok Bahadur Shrestha,
- Katie Tungatt,
- Anupriya Aggarwal,
- Aija Stubis,
- Nicole L. Fewings,
- Christina Fichter,
- Anouschka Akerman,
- Chaturaka Rodrigo,
- Nicodemus Tedla,
- Sharon Lee,
- Andrew R. Lloyd,
- Fabienne Brilot,
- Warwick J. Britton,
- Anthony Kelleher,
- Ian D. Caterson,
- Mark W. Douglas,
- Rebecca Rockett,
- Stuart G. Tangye,
- James A. Triccas,
- Stuart G. Turville,
- Kerrie J. Sandgren,
- Rowena A. Bull,
- Anthony L. Cunningham,
- Anthony L. Cunningham,
- Tania Sorrell,
- Anthony Kelleher,
- Warwick Britton,
- Mark Maclean,
- Sharon Lee,
- Joanne Camilleri,
- Mark Douglas,
- Rowena Bull,
- Kerrie Sandgren,
- Yang Song,
- Lijun Mao,
- Amy Phu,
- Allison Sigmund,
- Sophie Beard,
- Ian Caterson,
- Stephanie Hunt,
- Anne Marie Vande More,
- Rama Kandasamy,
- Ian Caterson,
- Jen Kok,
- Jennifer Byrne,
- Andrew Lloyd,
- James Triccas,
- Stuart Tangye,
- Stuart Turville,
- Fabienne Brilot,
- Matthew O’Sullivan,
- Megan Steain,
- Sarah Baird,
- Chansavath Phetsouphanh,
- Yanran Zhao
Affiliations
- Lok Bahadur Shrestha
- The Kirby Institute, University of New South Wales, Sydney, NSW, Australia; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, NSW, Australia
- Katie Tungatt
- Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia
- Anupriya Aggarwal
- The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
- Aija Stubis
- Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia
- Nicole L. Fewings
- Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia
- Christina Fichter
- The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
- Anouschka Akerman
- The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
- Chaturaka Rodrigo
- School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, NSW, Australia
- Nicodemus Tedla
- School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, NSW, Australia
- Sharon Lee
- Research & Education Network, Western Sydney Local Health District, Westmead, NSW, Australia
- Andrew R. Lloyd
- The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
- Fabienne Brilot
- Kids Neuroscience Centre, Kids Research at the Children’s Hospital at Westmead, Westmead, NSW, Australia; Sydney Infectious Diseases Institute (Sydney ID), Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia
- Warwick J. Britton
- Centenary Institute, The University of Sydney, Camperdown, NSW, Australia; RPAH Vaccination Centre, Sydney Local Health District, Sydney, NSW, Australia
- Anthony Kelleher
- The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
- Ian D. Caterson
- RPAH Vaccination Centre, Sydney Local Health District, Sydney, NSW, Australia
- Mark W. Douglas
- Sydney Infectious Diseases Institute (Sydney ID), Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia; Storr Liver Centre, The Westmead Institute for Medical Research, Westmead, NSW, Australia; Centre for Infectious Diseases and Microbiology, Westmead Hospital, Westmead, NSW, Australia
- Rebecca Rockett
- Sydney Infectious Diseases Institute (Sydney ID), Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia
- Stuart G. Tangye
- Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia
- James A. Triccas
- Sydney Infectious Diseases Institute (Sydney ID), Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia
- Stuart G. Turville
- The Kirby Institute, University of New South Wales, Sydney, NSW, Australia
- Kerrie J. Sandgren
- Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia; Sydney Infectious Diseases Institute (Sydney ID), Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia
- Rowena A. Bull
- The Kirby Institute, University of New South Wales, Sydney, NSW, Australia; School of Biomedical Sciences, Faculty of Medicine & Health, University of New South Wales, Sydney, NSW, Australia
- Anthony L. Cunningham
- Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia; Sydney Infectious Diseases Institute (Sydney ID), Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia; Corresponding author. Centre for Virus Research, The Westmead Institute for Medical Research, Westmead, NSW, Australia.
- Anthony L. Cunningham
- Tania Sorrell
- Anthony Kelleher
- Warwick Britton
- Mark Maclean
- Sharon Lee
- Joanne Camilleri
- Mark Douglas
- Rowena Bull
- Kerrie Sandgren
- Yang Song
- Lijun Mao
- Amy Phu
- Allison Sigmund
- Sophie Beard
- Ian Caterson
- Stephanie Hunt
- Anne Marie Vande More
- Rama Kandasamy
- Ian Caterson
- Jen Kok
- Jennifer Byrne
- Andrew Lloyd
- James Triccas
- Stuart Tangye
- Stuart Turville
- Fabienne Brilot
- Matthew O’Sullivan
- Megan Steain
- Sarah Baird
- Chansavath Phetsouphanh
- Yanran Zhao
- Journal volume & issue
-
Vol. 110
p. 105461
Abstract
Summary: Background: Current literature informs us that bivalent vaccines will generate a broader serum neutralizing antibody response to multiple SARS-CoV-2 variants, but studies on how this breadth relates to the memory B cell (MBC) and T cell responses are sparse. This study compared breadth of neutralising antibody, and memory B and T cell responses to monovalent or a bivalent ancestral/Omicron BA.1 COVID-19 booster vaccine. Methods: At baseline and 1-month post-booster, neutralisation activity and frequencies of receptor binding domain (RBD)-specific MBCs and Spike-specific memory T cells were measured against a panel of variants. Findings: Both vaccines boosted neutralising antibodies to 5 variants - Wuhan-Hu-1, Delta, BA.1, BA.5 and JN.1, the latter of which had not yet emerged at the time of sample collection. The bivalent vaccine induced a significantly larger increase in nAb against BA.1 and JN.1. Both vaccines boosted RBD-specific MBC responses to Wuhan-Hu-1, Delta, BA.1 and BA.5 variants with a significantly greater increase for BA.1 in the bivalent group. The breadth of MBCs was significantly higher in those who received the bivalent boost and correlated with nAb breadth. Both vaccines significantly boosted Spike-specific T cell responses to the Wuhan-Hu-1 and BA.5 variants, but only the bivalent vaccine boosted BA.1 responses. Interpretation: These results suggest that the bivalent vaccine confers an advantage against future novel variants due to increased frequency of broadly reactive RBD-specific B cells. Funding: Work supported by NSW Health for the NSW Vaccine, Infection and Immunology Collaborative (VIIM).
