Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

Jolanta Chmielowiec; Wojciech J. Szlachcic; Diane Yang; Marissa A. Scavuzzo; Katrina Wamble; Alejandro Sarrion-Perdigones; Omaima M. Sabek; Koen J. T. Venken; Malgorzata Borowiak

doi:10.1038/s41467-022-29646-1

Nature Communications (Apr 2022)

Human pancreatic microenvironment promotes β-cell differentiation via non-canonical WNT5A/JNK and BMP signaling

Jolanta Chmielowiec,
Wojciech J. Szlachcic,
Diane Yang,
Marissa A. Scavuzzo,
Katrina Wamble,
Alejandro Sarrion-Perdigones,
Omaima M. Sabek,
Koen J. T. Venken,
Malgorzata Borowiak

Affiliations

Jolanta Chmielowiec: Molecular and Cellular Biology Department, Baylor College of Medicine
Wojciech J. Szlachcic: Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University
Diane Yang: Molecular and Cellular Biology Department, Baylor College of Medicine
Marissa A. Scavuzzo: Program in Developmental Biology, Baylor College of Medicine
Katrina Wamble: Stem Cell and Regenerative Medicine Center, Baylor College of Medicine
Alejandro Sarrion-Perdigones: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Omaima M. Sabek: Department of Surgery, The Methodist Hospital
Koen J. T. Venken: Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Malgorzata Borowiak: Molecular and Cellular Biology Department, Baylor College of Medicine

DOI: https://doi.org/10.1038/s41467-022-29646-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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In vitro differentiation of pancreatic beta cells offers a potential therapeutic approach for diabetes. Here they show human pluripotent stem cell derived pancreatic progenitors differentiate into insulin-secreting cells by crosstalk of WNT5A and BMP signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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