Synthesis of (<i>R</i>) and (<i>S</i>)-3-Chloro-5-(3-methylmorpholino)-4<i>H</i>-1,2,6-thiadiazin-4-ones

Abstract

Reaction of 3,5-dichloro-4H-1,2,6-thiadiazin-4-one with (R) and (S)-3-methylmorpholines (2 equiv), in THF, at ca. 20 °C gave (R) and (S)-3-chloro-5-(3-methylmorpholino)-4H-1,2,6-thiadiazin-4-ones in 95 and 97% yields, respectively. The new compounds were fully characterized.

Keywords

• substitution
• heterocycle
• thiadiazine
• morpholine
• chirality