Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α‑Glucosidase II Inhibitor, Blocks Replication of SARS-CoV‑2 and Other Coronaviruses

• Melissa Thaler,
• Tim P. Ofman,
• Ken Kok,
• Jurriaan J. A. Heming,
• Elisha Moran,
• Isabelle Pickles,
• Anouk A. Leijs,
• Adrianus M. C. H. van den Nieuwendijk,
• Richard J. B. H. N. van den Berg,
• Gijs Ruijgrok,
• Zachary Armstrong,
• Clarisse Salgado-Benvindo,
• Dennis K. Ninaber,
• Eric J. Snijder,
• Constant A. A. van Boeckel,
• Marta Artola,
• Gideon J. Davies,
• Herman S. Overkleeft,
• Martijn J. van Hemert

Affiliations

Melissa Thaler

Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands

Tim P. Ofman

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Ken Kok

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Jurriaan J. A. Heming

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Elisha Moran

Department of Chemistry, University of York, York, United Kingdom

Isabelle Pickles

Department of Chemistry, University of York, York, United Kingdom

Anouk A. Leijs

Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands

Adrianus M. C. H. van den Nieuwendijk

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Richard J. B. H. N. van den Berg

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Gijs Ruijgrok

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Zachary Armstrong

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Clarisse Salgado-Benvindo

Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands

Dennis K. Ninaber

Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands

Eric J. Snijder

Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands

Constant A. A. van Boeckel

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Marta Artola

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Gideon J. Davies

Department of Chemistry, University of York, York, United Kingdom

Herman S. Overkleeft

Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands

Martijn J. van Hemert

Leiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands