Glacial acetic acid as an efficient catalyst for simple synthesis of dindolylmethanes

Abstract

Glacial acetic acid as a protic acid was employed as a catalyst in a solvent free condition for facile preparation of di(indolyl)methanes (DIMs) via one-pot condensation of indole with aryl or heteroaryl aldehydes. Various aryl and heteroaryl aldehydes were efficiently converted to the corresponding di(indolyl)methanes (1a-p) in high yields. The described novel synthetic method proposes several advantages of safety, mild condition, short reaction times, high yields, simplicity and the inexpensively glacial acetic acid compared to other catalysts.

Keywords

• Aromatic aldehydes
• Bisindolylmethane
• Glacial acetic acid
• Solvent free conditions