Nature Communications (May 2018)
The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma
- Bill H. Diplas,
- Xujun He,
- Jacqueline A. Brosnan-Cashman,
- Heng Liu,
- Lee H. Chen,
- Zhaohui Wang,
- Casey J. Moure,
- Patrick J. Killela,
- Daniel B. Loriaux,
- Eric S. Lipp,
- Paula K. Greer,
- Rui Yang,
- Anthony J. Rizzo,
- Fausto J. Rodriguez,
- Allan H. Friedman,
- Henry S. Friedman,
- Sizhen Wang,
- Yiping He,
- Roger E. McLendon,
- Darell D. Bigner,
- Yuchen Jiao,
- Matthew S. Waitkus,
- Alan K. Meeker,
- Hai Yan
Affiliations
- Bill H. Diplas
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Xujun He
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Jacqueline A. Brosnan-Cashman
- Department of Pathology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine
- Heng Liu
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Lee H. Chen
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Zhaohui Wang
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Casey J. Moure
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Patrick J. Killela
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Daniel B. Loriaux
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Eric S. Lipp
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Paula K. Greer
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Rui Yang
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Anthony J. Rizzo
- Department of Pathology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine
- Fausto J. Rodriguez
- Department of Pathology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine
- Allan H. Friedman
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Henry S. Friedman
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Sizhen Wang
- Genetron Health (Beijing) Co. Ltd
- Yiping He
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Roger E. McLendon
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Darell D. Bigner
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Yuchen Jiao
- State Key Laboratory of Molecular Oncology, Laboratory of Cell and Molecular Biology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Matthew S. Waitkus
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- Alan K. Meeker
- Department of Pathology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine
- Hai Yan
- The Preston Robert Tisch Brain Tumor Center at Duke, Duke University Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-04448-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERT p WT-IDH WT glioblastoma). Here, the authors present a genetic landscape of TERTp WT-IDH WT glioblastoma, identifying a telomerase-positive subgroup driven by TERT-structural rearrangements and an ALT-positive subgroup with mutations in ATRX or SMARCAL1.
