Nature Communications (Oct 2022)
Endothelial cell cycle state determines propensity for arterial-venous fate
- Nicholas W. Chavkin,
- Gael Genet,
- Mathilde Poulet,
- Erin D. Jeffery,
- Corina Marziano,
- Nafiisha Genet,
- Hema Vasavada,
- Elizabeth A. Nelson,
- Bipul R. Acharya,
- Anupreet Kour,
- Jordon Aragon,
- Stephanie P. McDonnell,
- Mahalia Huba,
- Gloria M. Sheynkman,
- Kenneth Walsh,
- Karen K. Hirschi
Affiliations
- Nicholas W. Chavkin
- Department of Cell Biology, University of Virginia School of Medicine
- Gael Genet
- Department of Cell Biology, University of Virginia School of Medicine
- Mathilde Poulet
- Department of Medicine, Yale Cardiovascular Research Center Yale University School of Medicine
- Erin D. Jeffery
- Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine
- Corina Marziano
- Department of Cell Biology, University of Virginia School of Medicine
- Nafiisha Genet
- Department of Cell Biology, University of Virginia School of Medicine
- Hema Vasavada
- Department of Medicine, Yale Cardiovascular Research Center Yale University School of Medicine
- Elizabeth A. Nelson
- Department of Cell Biology, University of Virginia School of Medicine
- Bipul R. Acharya
- Department of Cell Biology, University of Virginia School of Medicine
- Anupreet Kour
- Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Jordon Aragon
- Department of Cell Biology, University of Virginia School of Medicine
- Stephanie P. McDonnell
- Department of Cell Biology, University of Virginia School of Medicine
- Mahalia Huba
- Department of Cell Biology, University of Virginia School of Medicine
- Gloria M. Sheynkman
- Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine
- Kenneth Walsh
- Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine
- Karen K. Hirschi
- Department of Cell Biology, University of Virginia School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-33324-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
During blood vessel development, endothelial cells become specified toward arterial or venous fates. Chavkin et al find that distinct endothelial cell cycle states provide windows of opportunity for the molecular induction of arterial or venous fate.
