Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer

• Roy S Herbst,
• Vamsidhar Velcheti,
• Mari Mino-Kenudson,
• Matthew D Hellmann,
• David L Rimm,
• Kurt A Schalper,
• Anant Madabhushi,
• Justin Gainor,
• Germán Corredor,
• Miguel Lopez de Rodas,
• Venkata Nagineni,
• Arvind Ravi,
• Ila J Datar,
• Cristian Barrera,
• Lindsey Behlman,
• Jonathan W Riess

Affiliations

Roy S Herbst

Medical Oncology, Yale Cancer Center | Yale School of Medicine | Smilow Cancer Hospital at Yale New Haven, New Haven, Connecticut, USA

Vamsidhar Velcheti

Aff307 grid.239578.20000000106754725Cleveland Clinic Cleveland OH USA

Mari Mino-Kenudson

Aff3 000000041936754Xgrid.38142.3cHarvard Medical School Boston MA USA

Matthew D Hellmann

Aff2 grid.51462.340000 0001 2171 9952Memorial Sloan-Kettering Cancer CenterMelanoma and Immunotherapeutics Oncology Service 300 East 66th Street 10065 New York NY USA

David L Rimm

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA

Kurt A Schalper

Pathology, Yale School of Medicine, New Haven, Connecticut, USA

Anant Madabhushi

Center for Computational Imaging and Personalized Diagnostics, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA

Justin Gainor

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA

Germán Corredor

Center for Computational Imaging and Personalized Diagnostics, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA

Miguel Lopez de Rodas

Department of Pathology and Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA

Venkata Nagineni

Department of Pathology and Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA

Arvind Ravi

Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA

Ila J Datar

Department of Pathology and Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA

Cristian Barrera

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA

Lindsey Behlman

Department of Pathology and Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA

Jonathan W Riess

UC Davis Comprenhensive Cancer Center, Sacramento, California, USA