Microorganisms (Feb 2022)

Inactivation of Opportunistic Pathogens <i>Acinetobacter baumannii</i> and <i>Stenotrophomonas maltophilia</i> by Antimicrobial Photodynamic Therapy

  • Irina Buchovec,
  • Laurita Klimkaitė,
  • Edita Sužiedėlienė,
  • Saulius Bagdonas

DOI
https://doi.org/10.3390/microorganisms10030506
Journal volume & issue
Vol. 10, no. 3
p. 506

Abstract

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Acinetobacter baumannii and Stenotrophomonas maltophilia are opportunistic pathogens causing hospital infections with limited treatment options due to bacterial multidrug resistance. Here, we report that antimicrobial photodynamic therapy (aPDT) based on the natural photosensitizers riboflavin and chlorophyllin inactivates A. baumannii and S. maltophilia. The riboflavin and chlorophyllin photostability experiments assessed the photomodifications of photosensitizers under the conditions subsequently used to inactivate A. baumannii and S. maltophilia. A. baumannii planktonic cells were more sensitive to riboflavin-aPDT, while biofilm bacteria were more efficiently inactivated by chlorophyllin-aPDT. S. maltophilia planktonic and biofilm cells were more susceptible to chlorophyllin-aPDT compared to riboflavin-aPDT. The results suggest that riboflavin- and chlorophyllin-aPDT can be considered as a potential antimicrobial treatment for A. baumannii and S. maltophilia inactivation.

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