mRNA Technologies Danger

Abstract

Highlights. The impact that the technologies may exert on human genome is underestimated. The mRNA technologies may represent a particular danger for human genome.Relevance. The mRNA technologies are quite widespread in the Western world. They are also gaining popularity in Russia and that is why we should control the safety of such technologies.Purpose of the study – to determine potential hazard of mRNA technologiesStudy base sources – full English academic periodicals available on the Internet.Method of the study. Analytical. The author used suggestions of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).Discussion. The paper dwells on the essence and scope of mRNA technologies, discusses their way of functioning, identifies their shortcomings that may provoke pathological consequences for humans; determines approaches that permit to use these technologies to control human genes. The article proves that nowadays the mRNA technologies are imperfect, for now it is impossible to predict near and long-term consequences that they may bring to human health. The technology itself is of a dual purpose and can be used under other names to unleash a biological war with a new final goal – to provoke a population decline. The newer the agents that may influence human genome will be, the more dangerous they will become. The methods of their application will also be more sophisticated. All this will be accompanied by media war that will eliminate alternative opinions. This will result in decline in the general level of knowledge about biological threats.Conclusion. We should maintain rigid state control over the development of any technologies that may potentially exert any impact on human genome. We should also ensure that such technologies are not used under other names. It is worth limiting the application of the mRNA technologies and to use them only in oncology approximately for 10 years. This will help to identify the range of possible adverse consequences of their application. All injection drugs that go to Russia from abroad should be checked for possible nano objects “storage”.

Keywords

• crispri/cas
• expression cassette
• genome editing
• human genome
• lipid nanoparticle
• lipoplexes
• liposome
• mrna technologies
• nanoconstruction
• polyplexes