3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia

Lu Yang; Fengling Chen; Haichuan Zhu; Yang Chen; Bingjie Dong; Minglei Shi; Weitao Wang; Qian Jiang; Leping Zhang; Xiaojun Huang; Michael Q. Zhang; Hong Wu

doi:10.1038/s41467-021-24044-5

Nature Communications (Jun 2021)

3D genome alterations associated with dysregulated HOXA13 expression in high-risk T-lineage acute lymphoblastic leukemia

Lu Yang,
Fengling Chen,
Haichuan Zhu,
Yang Chen,
Bingjie Dong,
Minglei Shi,
Weitao Wang,
Qian Jiang,
Leping Zhang,
Xiaojun Huang,
Michael Q. Zhang,
Hong Wu

Affiliations

Lu Yang: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Fengling Chen: MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University
Haichuan Zhu: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Yang Chen: MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University
Bingjie Dong: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Minglei Shi: MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University
Weitao Wang: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University
Qian Jiang: Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease
Leping Zhang: Department of Pediatrics, Peking University People’s Hospital
Xiaojun Huang: Peking-Tsinghua Center for Life Sciences
Michael Q. Zhang: MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, Bioinformatics Division, BNRist, Department of Automation, Tsinghua University
Hong Wu: The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University

DOI: https://doi.org/10.1038/s41467-021-24044-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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The non-coding genome of T-ALL has not been extensively studied. Here, the authors conduct RNA-seq, ATAC-seq and Hi-C seq analyses and find that T-ALL associated neo-loops may regulate key transcription factors including HOXA13; the aberrant expression of which is associated with poor prognosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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