Biological Evaluation of a Mitochondrial Phosphoenolpyruvate Carboxykinase Inhibitor

Sergio Rodríguez-Arévalo; Sònia Abás; Marc Aragó; Juan Moreno-Felici; Petra Hyroššová; Jose Carlos Perales; Carles Galdeano; Tiziana Ginex; Francisco Javier Luque; Carmen Escolano

doi:10.3390/proceedings2019022095

Proceedings (Sep 2019)

Biological Evaluation of a Mitochondrial Phosphoenolpyruvate Carboxykinase Inhibitor

Sergio Rodríguez-Arévalo,
Sònia Abás,
Marc Aragó,
Juan Moreno-Felici,
Petra Hyroššová,
Jose Carlos Perales,
Carles Galdeano,
Tiziana Ginex,
Francisco Javier Luque,
Carmen Escolano

Affiliations

Sergio Rodríguez-Arévalo: Laboratory of Medicinal Chemistry (Associated unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain
Sònia Abás: Laboratory of Medicinal Chemistry (Associated unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain
Marc Aragó: Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain
Juan Moreno-Felici: Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain
Petra Hyroššová: Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain
Jose Carlos Perales: Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Barcelona 08907, Spain
Carles Galdeano: Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine of the University of Barcelona (IBUB), University of Barcelona, Barcelona 08028, Spain
Tiziana Ginex: Departament de Nutrició, Ciències de l’Alimentació i Gastronomia, Faculty of Pharmacy, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08921, Spain
Francisco Javier Luque: Departament de Nutrició, Ciències de l’Alimentació i Gastronomia, Faculty of Pharmacy, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08921, Spain
Carmen Escolano: Laboratory of Medicinal Chemistry (Associated unit to CSIC), Department of Pharmacology, Toxicology and Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), University of Barcelona, Barcelona 08028, Spain

DOI: https://doi.org/10.3390/proceedings2019022095
Journal volume & issue: Vol. 22, no. 1
p. 95

Abstract

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Phosphoenolpyruvate carboxykinase (PEPCK) is a key enzyme in gluconeogenesis, catalyzingthe decarboxylation of oxaloacetate to phosphoenolpyruvate. [...]

Published in Proceedings

ISSN: 2504-3900 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: General Works
Website: http://www.mdpi.com/journal/proceedings

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