Nature Communications (Oct 2022)
DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon
- Antonella Fazio,
- Dora Bordoni,
- Jan W. P. Kuiper,
- Saskia Weber-Stiehl,
- Stephanie T. Stengel,
- Philipp Arnold,
- David Ellinghaus,
- Go Ito,
- Florian Tran,
- Berith Messner,
- Anna Henning,
- Joana P. Bernardes,
- Robert Häsler,
- Anne Luzius,
- Simon Imm,
- Finn Hinrichsen,
- Andre Franke,
- Samuel Huber,
- Susanna Nikolaus,
- Konrad Aden,
- Stefan Schreiber,
- Felix Sommer,
- Gioacchino Natoli,
- Neha Mishra,
- Philip Rosenstiel
Affiliations
- Antonella Fazio
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Dora Bordoni
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Jan W. P. Kuiper
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Saskia Weber-Stiehl
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Stephanie T. Stengel
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Philipp Arnold
- Institute of Functional and Clinical Anatomy, Friedrich-Alexander-University Erlangen-Nürnberg (FAU)
- David Ellinghaus
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Go Ito
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Florian Tran
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Berith Messner
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Anna Henning
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Joana P. Bernardes
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Robert Häsler
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Anne Luzius
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Simon Imm
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Finn Hinrichsen
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Andre Franke
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Samuel Huber
- I. Department of Medicine, University Medical Center Hamburg-Eppendorf
- Susanna Nikolaus
- Department of Internal Medicine I., Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Konrad Aden
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Stefan Schreiber
- Department of Internal Medicine I., Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Felix Sommer
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Gioacchino Natoli
- Department of Experimental Oncology, European Institute of Oncology IRCCS (IEO)
- Neha Mishra
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- Philip Rosenstiel
- Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein
- DOI
- https://doi.org/10.1038/s41467-022-33844-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
DNA methyltransferase 3 A (DNMT3A) is involved in DNA methylation, and genetic variants in the DNMT3 locus have been associated with inflammatory bowel disease. Here the authors report that DNMT3A controls intestinal epithelial barrier function and restoration of the gut barrier function after intestinal epithelial perturbation.
