Haematologica (Apr 2007)

Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes

  • Oleksii A. Skorokhod,
  • Elena V. Kulikova,
  • Ninel M. Galkina,
  • Pavel V. Medvedev,
  • Elena E. Zybunova,
  • Victor M. Vitvitsky,
  • Aleksandr V. Pivnik,
  • Fazoil I. Ataullakhanov

DOI
https://doi.org/10.3324/haematol.10770
Journal volume & issue
Vol. 92, no. 4

Abstract

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Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.