Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

Abstract

The use of mouse models has been an invaluable resource in cancer research but their generation is lengthy and costly. Here the authors describe an approach to generate engineered mouse models carrying specific gene fusions and, as a proof of principle, show that Bcan-Ntrk1 fusion leads to glioblastomas.