Post-translational modifications of pyruvate dehydrogenase complex in cardiovascular disease

Bo Guo; Fujiao Zhang; Yue Yin; Xingmin Ning; Zihui Zhang; Qinglei Meng; Ziqi Yang; Wenhua Jiang; Manling Liu; Yishi Wang; Lijuan Sun; Lu Yu; Nan Mu

iScience (Sep 2024)

Post-translational modifications of pyruvate dehydrogenase complex in cardiovascular disease

Bo Guo,
Fujiao Zhang,
Yue Yin,
Xingmin Ning,
Zihui Zhang,
Qinglei Meng,
Ziqi Yang,
Wenhua Jiang,
Manling Liu,
Yishi Wang,
Lijuan Sun,
Lu Yu,
Nan Mu

Affiliations

Bo Guo: Department of Pharmacy, Northwest Woman’s and Children’s Hospital, Xi’an, China
Fujiao Zhang: College of Life Sciences, Northwest University, Xi’an, China
Yue Yin: Department of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China
Xingmin Ning: College of Life Sciences, Northwest University, Xi’an, China
Zihui Zhang: Institute of Medical Research, Northwestern Polytechnical University, Xi’an, China
Qinglei Meng: College of Life Sciences, Yan’an University, Yan’an, China
Ziqi Yang: Department of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China
Wenhua Jiang: Institute of Medical Research, Northwestern Polytechnical University, Xi’an, China
Manling Liu: Department of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China
Yishi Wang: Department of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China
Lijuan Sun: Eye Institute of Chinese PLA and Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi’an, China; Corresponding author
Lu Yu: Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi’an, China; Corresponding author
Nan Mu: Department of Physiology and Pathophysiology, School of Basic Medicine, Fourth Military Medical University, Xi’an, China; Corresponding author

Journal volume & issue: Vol. 27, no. 9
p. 110633

Abstract

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Summary: Pyruvate dehydrogenase complex (PDC) is a crucial enzyme that connects glycolysis and the tricarboxylic acid (TCA) cycle pathway. It plays an essential role in regulating glucose metabolism for energy production by catalyzing the oxidative decarboxylation of pyruvate to acetyl coenzyme A. Importantly, the activity of PDC is regulated through post-translational modifications (PTMs), phosphorylation, acetylation, and O-GlcNAcylation. These PTMs have significant effects on PDC activity under both physiological and pathophysiological conditions, making them potential targets for metabolism-related diseases. This review specifically focuses on the PTMs of PDC in cardiovascular diseases (CVDs) such as myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, obesity-related cardiomyopathy, heart failure (HF), and vascular diseases. The findings from this review offer theoretical references for the diagnosis, treatment, and prognosis of CVD.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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