The Influence of Proteins on Fate and Biological Role of Circulating DNA

Abstract

Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA’s fate in circulation and its biological role. In this review, we attempt to shed light on current ideas about circulating DNA origins and forms of circulation, known biological effects, and the clinical potential of circulating tumor deoxyribonucleoprotein complexes.

Keywords

• circulating DNA
• cell-free tumor DNA
• cell surface-bound DNA
• DNA-binding proteins
• extracellular vesicles
• exosomes