Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder

Daoyan Wu; Mei Cao; Jie Zhou; Shiying Yan; Jingshan Peng; Zhihao Yu; Andong Zhang; Jialin Wu; Xin Yan; Jian Zhao

Journal of Functional Foods (Oct 2021)

Lactobacillus casei T1 from kurut against Helicobacter pylori-induced inflammation and the gut microbial disorder

Daoyan Wu,
Mei Cao,
Jie Zhou,
Shiying Yan,
Jingshan Peng,
Zhihao Yu,
Andong Zhang,
Jialin Wu,
Xin Yan,
Jian Zhao

Affiliations

Daoyan Wu: Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China; Department of Microbiology, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, PR China
Mei Cao: Core Laboratory, School of Medicine, Sichuan Provincial People’s Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu 610072, PR China
Jie Zhou: Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China
Shiying Yan: Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China
Jingshan Peng: Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China
Zhihao Yu: Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China
Andong Zhang: Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China
Jialin Wu: Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China
Xin Yan: Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China
Jian Zhao: Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu 610064, PR China; Corresponding author.

Journal volume & issue: Vol. 85
p. 104611

Abstract

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Probiotics have the functions of inhibiting pathogen infection and maintaining gastrointestinal homeostasis. The aim of this study was to investigate the preventive effect of Lactobacillus casei T1 (L. casei T1) isolated from kurut against the gastric inflammation and gut microbiota alteration induced by Helicobacter pylori (H. pylori) infection. The results showed that L. casei T1 and its supernatant had a potent inhibitory effect on H. pylori growth in vitro. L. casei T1 adhered to GES-1 cells, down-regulated the expression of MUC5AC, IL-6, IL-8 and TNF-α in GES-1 cells induced by H. pylori. This followed by in vivo studies demonstrated that L. casei T1 pretreatment alleviated gastric inflammation and prevent gut microbiota alteration caused by H. pylori infection. These results demonstrated that L. casei T1 have a preventive effect against H. pylori infection and it can be served as a further development and utilization of probiotic.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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