Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

Jie Xu; Yan Sun; Yize Li; Gordon Ruthel; Susan R. Weiss; Arjun Raj; Daniel Beiting; Carolina B. López

doi:10.1038/s41467-017-00909-6

Nature Communications (Oct 2017)

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

Jie Xu,
Yan Sun,
Yize Li,
Gordon Ruthel,
Susan R. Weiss,
Arjun Raj,
Daniel Beiting,
Carolina B. López

Affiliations

Jie Xu: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania
Yan Sun: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania
Yize Li: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania
Gordon Ruthel: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania
Susan R. Weiss: Department of Microbiology, Perelman School of Medicine, University of Pennsylvania
Arjun Raj: Department of Bioengineering, School of Engineering, University of Pennsylvania
Daniel Beiting: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania
Carolina B. López: Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania

DOI: https://doi.org/10.1038/s41467-017-00909-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Replication defective viral genomes (DVGs) can facilitate persistence of paramyxoviruses, but the underlying mechanisms are unclear. Using FISH, Xu et al. here analyze the cellular response to DVGs on a single cell level and show that a MAVS-mediated TNF response specifically extends survival of cells enriched in DVGs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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