Nature Communications (Nov 2022)
Cancer cell survival depends on collagen uptake into tumor-associated stroma
- Kuo-Sheng Hsu,
- James M. Dunleavey,
- Christopher Szot,
- Liping Yang,
- Mary Beth Hilton,
- Karen Morris,
- Steven Seaman,
- Yang Feng,
- Emily M. Lutz,
- Robert Koogle,
- Francesco Tomassoni-Ardori,
- Saurabh Saha,
- Xiaoyan M. Zhang,
- Enrique Zudaire,
- Pradip Bajgain,
- Joshua Rose,
- Zhongyu Zhu,
- Dimiter S. Dimitrov,
- Frank Cuttitta,
- Nancy J. Emenaker,
- Lino Tessarollo,
- Brad St. Croix
Affiliations
- Kuo-Sheng Hsu
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- James M. Dunleavey
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Christopher Szot
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Liping Yang
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Mary Beth Hilton
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Karen Morris
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Steven Seaman
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Yang Feng
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Emily M. Lutz
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Robert Koogle
- MCGP, NCI
- Francesco Tomassoni-Ardori
- MCGP, NCI
- Saurabh Saha
- BioMed Valley Discoveries, Inc
- Xiaoyan M. Zhang
- BioMed Valley Discoveries, Inc
- Enrique Zudaire
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Pradip Bajgain
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Joshua Rose
- Biomolecular Structure Section, Center for Structural Biology, NCI, NIH
- Zhongyu Zhu
- Protein Interactions Section, Cancer and Inflammation Program, NCI, NIH
- Dimiter S. Dimitrov
- Protein Interactions Section, Cancer and Inflammation Program, NCI, NIH
- Frank Cuttitta
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- Nancy J. Emenaker
- Division of Cancer Prevention, NCI, NIH
- Lino Tessarollo
- Neural Development Section, MCGP, NCI, NIH
- Brad St. Croix
- Tumor Angiogenesis Unit, Mouse Cancer Genetics Program (MCGP), National Cancer Institute (NCI)
- DOI
- https://doi.org/10.1038/s41467-022-34643-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative energy source for tumour cells to grow.
