Globus pallidus internus activity increases during voluntary movement in children with dystonia

Estefania Hernandez-Martin; Maral Kasiri; Sumiko Abe; Jennifer MacLean; Joffre Olaya; Mark Liker; Jason Chu; Terence D. Sanger

iScience (Jul 2023)

Globus pallidus internus activity increases during voluntary movement in children with dystonia

Estefania Hernandez-Martin,
Maral Kasiri,
Sumiko Abe,
Jennifer MacLean,
Joffre Olaya,
Mark Liker,
Jason Chu,
Terence D. Sanger

Affiliations

Estefania Hernandez-Martin: Department of Electrical Engineering and Computer Science, University of California, Irvine, Irvine, CA, USA; Corresponding author
Maral Kasiri: Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA
Sumiko Abe: Department of Electrical Engineering and Computer Science, University of California, Irvine, Irvine, CA, USA
Jennifer MacLean: Department of Neurosurgery and Neurology, Children’s Hospital of Orange County (CHOC), Orange, CA, USA
Joffre Olaya: Department of Neurosurgery and Neurology, Children’s Hospital of Orange County (CHOC), Orange, CA, USA
Mark Liker: Department of Neurosurgery, University of Southern California, Los Angeles, CA, USA
Jason Chu: Department of Neurosurgery, University of Southern California, Los Angeles, CA, USA
Terence D. Sanger: Department of Electrical Engineering and Computer Science, University of California, Irvine, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA; Department of Neurosurgery and Neurology, Children’s Hospital of Orange County (CHOC), Orange, CA, USA

Journal volume & issue: Vol. 26, no. 7
p. 107066

Abstract

Read online

Summary: The rate model of basal ganglia function predicts that muscle activity in dystonia is due to disinhibition of thalamus resulting from decreased inhibitory input from pallidum. We seek to test this hypothesis in children with dyskinetic cerebral palsy undergoing evaluation for deep brain stimulation (DBS) to analyze movement-related activity in different brain regions. The results revealed prominent beta-band frequency peaks in the globus pallidus interna (GPi), ventral oralis anterior/posterior (VoaVop) subnuclei of the thalamus, and subthalamic nucleus (STN) during movement but not at rest. Connectivity analysis indicated stronger coupling between STN-VoaVop and STN-GPi compared to GPi-STN. These findings contradict the hypothesis of decreased thalamic inhibition in dystonia, suggesting that abnormal patterns of inhibition and disinhibition, rather than reduced GPi activity, contribute to the disorder. Additionally, the study implies that correcting abnormalities in GPi function may explain the effectiveness of DBS targeting the STN and GPi in treating dystonia.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

About the journal

Abstract

Keywords