PLoS ONE (Jan 2021)

The systemic inflammatory response and clinicopathological characteristics in patients admitted to hospital with COVID-19 infection: Comparison of 2 consecutive cohorts.

  • Donogh Maguire,
  • Conor Richards,
  • Marylynne Woods,
  • Ross Dolan,
  • Jesse Wilson Veitch,
  • Wei M J Sim,
  • Olivia E H Kemmett,
  • David C Milton,
  • Sophie L W Randall,
  • Ly D Bui,
  • Nicola Goldmann,
  • Amy Brown,
  • Eilidh Gillen,
  • Allan Cameron,
  • Barry Laird,
  • Dinesh Talwar,
  • Ian M Godber,
  • John Wadsworth,
  • Anthony Catchpole,
  • Alan Davidson,
  • Donald C McMillan

DOI
https://doi.org/10.1371/journal.pone.0251924
Journal volume & issue
Vol. 16, no. 5
p. e0251924

Abstract

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BackgroundIn order to manage the COVID-19 systemic inflammatory response, it is important to identify clinicopathological characteristics across multiple cohorts.MethodsThe aim of the present study was to compare the 4C mortality score, other measures of the systemic inflammatory response and clinicopathological characteristics in two consecutive cohorts of patients on admission with COVID-19. Electronic patient records for 2 consecutive cohorts of patients admitted to two urban teaching hospitals with COVID-19 during two 7-week periods of the COVID-19 pandemic in Glasgow, U.K. (cohort 1: 17/3/2020-1/5/2020) and (cohort 2: 18/5/2020-6/7/2020) were examined for routine clinical, laboratory and clinical outcome data.ResultsCompared with cohort 1, cohort 2 were older (p70 (p150mg/L (p3) (OR 11.3, 95% C.I. 2.3-96.7, pConclusionIn addition to the 4C mortality score, frailty score and a low albumin were strongly independently associated with 30-day mortality in two consecutive cohorts of patients admitted to hospital with COVID-19.Trial registrationclinicaltrials.gov: NCT04484545.