Breast (Aug 2024)
6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7)
- Fatima Cardoso,
- Shani Paluch-Shimon,
- Eva Schumacher-Wulf,
- Leonor Matos,
- Karen Gelmon,
- Matti S. Aapro,
- Jyoti Bajpai,
- Carlos H. Barrios,
- Jonas Bergh,
- Elizabeth Bergsten-Nordström,
- Laura Biganzoli,
- Maria João Cardoso,
- Lisa A. Carey,
- Mariana Chavez-MacGregor,
- Runcie Chidebe,
- Javier Cortés,
- Giuseppe Curigliano,
- Rebecca A. Dent,
- Nagi S. El Saghir,
- Alexandru Eniu,
- Lesley Fallowfield,
- Prudence A. Francis,
- Sandra X. Franco Millan,
- Jenny Gilchrist,
- Joseph Gligorov,
- William J. Gradishar,
- Renate Haidinger,
- Nadia Harbeck,
- Xichun Hu,
- Ranjit Kaur,
- Belinda Kiely,
- Sung-Bae Kim,
- Smruti Koppikar,
- Marion J.J. Kuper-Hommel,
- Frédéric E. Lecouvet,
- Ginny Mason,
- Shirley A. Mertz,
- Volkmar Mueller,
- Claire Myerson,
- Silvia Neciosup,
- Birgitte V. Offersen,
- Shinji Ohno,
- Olivia Pagani,
- Ann H. Partridge,
- Frédérique Penault-Llorca,
- Aleix Prat,
- Hope S. Rugo,
- Elzbieta Senkus,
- George W. Sledge,
- Sandra M. Swain,
- Christoph Thomssen,
- Daniel A. Vorobiof,
- Peter Vuylsteke,
- Theresa Wiseman,
- Binghe Xu,
- Alberto Costa,
- Larry Norton,
- Eric P. Winer
Affiliations
- Fatima Cardoso
- Breast Unit, Champalimaud Clinical Centre/Champalimaud Foundation, and ABC Global Alliance, Lisbon, Portugal; Corresponding author. Breast Unit, Champalimaud Clinical Center, Av. De Brasília s/n, 1400-038, Lisbon, Portugal.
- Shani Paluch-Shimon
- Hadassah University Hospital - Sharett Institute of Oncology, Jerusalem, Israel
- Eva Schumacher-Wulf
- Mamma Mia, Kronberg, Germany
- Leonor Matos
- Breast Unit, Champalimaud Clinical Centre/Champalimaud Foundation, Lisbon, Portugal
- Karen Gelmon
- BC Cancer Agency, Department of Medical Oncology, Vancouver, Canada
- Matti S. Aapro
- Cancer Center, Clinique de Genolier, Genolier, Switzerland
- Jyoti Bajpai
- Tata Memorial Centre, HBNI, Mumbai, India
- Carlos H. Barrios
- Latin American Cooperative Oncology Group (LACOG), Grupo Oncoclínicas, Porto Alegre, Brazil
- Jonas Bergh
- Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden
- Elizabeth Bergsten-Nordström
- Europa Donna - the European Breast Cancer Coalition, Norrkoping, Sweden
- Laura Biganzoli
- Department of Oncology, Hospital of Prato - Azienda USL Toscana Centro Prato, Italy and European Society of Breast Cancer Specialists (EUSOMA), Italy
- Maria João Cardoso
- Breast Unit, Champalimaud Clinical Centre/Champalimaud Foundation and Lisbon University, Faculty of Medicine, Lisbon, Portugal
- Lisa A. Carey
- UNC Lineberger Comprehensive Cancer Center, Chapel Hill, USA
- Mariana Chavez-MacGregor
- Health Services Research, Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, USA and American Society of Clinical Oncology (ASCO), Houston, USA
- Runcie Chidebe
- Project PINKBLUE, Abuja, Nigeria
- Javier Cortés
- International Breast Cancer Center (IBCC), Madrid and Barcelona, Spain
- Giuseppe Curigliano
- European Institute of Oncology, IRCCS, Milano, Italy; Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy
- Rebecca A. Dent
- National Cancer Center Singapore, Singapore, Singapore
- Nagi S. El Saghir
- NK Basile Cancer Institute, American University of Beirut Medical Center, Beirut, Lebanon
- Alexandru Eniu
- Hôpital Riviera-Chablais, Vaud-Valais Rennaz, Switzerland and European School of Oncology (ESO), United Kingdom
- Lesley Fallowfield
- Brighton & Sussex Medical School, University of Sussex, Brighton, United Kingdom
- Prudence A. Francis
- Department of Medical Oncology, Peter MacCallum Cancer Centre, Sir Peter MacCallum Department of Oncology, University of Melbourne, Australia
- Sandra X. Franco Millan
- CTIC, Cancer Treatment and Research Center, Bogotá, Colombia
- Jenny Gilchrist
- Macquarie University, Sydney, Australia
- Joseph Gligorov
- Department of Medical Oncology, Cancer Est APHP Tenon, University Paris VI, Nice/St Paul Guidelines, Paris, France
- William J. Gradishar
- Northwestern Medicine, Illinois, USA and National Comprehensive Cancer Network (NCCN), USA
- Renate Haidinger
- Brustkrebs Deutschland e.V., Munich, Germany
- Nadia Harbeck
- Breast Centre, University of Munich, Munich and Arbeitsgemeinschaft Gynäkologische Onkologie, Kommission Mamma (AGO Guidelines), Germany
- Xichun Hu
- Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
- Ranjit Kaur
- Breast Cancer Welfare Association, Petaling Jaya, Malaysia
- Belinda Kiely
- NHMRC Clinical Trials Centre, Sydney Medical School, Sydney, Australia
- Sung-Bae Kim
- Asan Medical Centre, Department of Oncology, Seoul, South Korea
- Smruti Koppikar
- Lilavati Hospital and Research Centre, Bombay Hospital Institute of Medical Sciences, Asian Cancer Institute, Mumbai, India
- Marion J.J. Kuper-Hommel
- Te Whatu Ora Waikato, Midland Regional Cancer Centre, NZ ABC Guidelines, Hamilton, New Zealand
- Frédéric E. Lecouvet
- Department of Radiology, Institut Roi Albert II and Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium
- Ginny Mason
- Inflammatory Breast Cancer Research Foundation, West Lafayette, USA
- Shirley A. Mertz
- MBC US Alliance and Metastatic Breast Cancer Network US, Inverness, USA
- Volkmar Mueller
- University Medical Center Hamburg-Eppendorf, Hamburg and Arbeitsgemeinschaft Gynäkologische Onkologie, Kommission Mamma (AGO Guidelines), Germany
- Claire Myerson
- Breast Cancer Now, London, United Kingdom
- Silvia Neciosup
- Department of Medical Oncology, National Institute of Neoplastic Diseases, Lima, ABC Latin America Guidelines, Peru
- Birgitte V. Offersen
- Department of Oncology, Aarhus University Hospital, Aarhus, European Society for Radiotherapy and Oncology (ESTRO), Denmark
- Shinji Ohno
- Breast Oncology Centre, Cancer Institute Hospital, Tokyo, Japan
- Olivia Pagani
- Hôpital Riviera-Chablais, Vaud-Valais Rennaz, Switzerland
- Ann H. Partridge
- Dana-Farber Cancer Institute, Department of Medical Oncology and Division of Breast Oncology, Boston, USA and American Society of Clinical Oncology (ASCO), USA
- Frédérique Penault-Llorca
- Centre Jean Perrin, Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégies Théranostiques, F-63000, Clermont Ferrand, Nice/St Paul Guidelines, France
- Aleix Prat
- Hospital Clínic of Barcelona, University of Barcelona, Barcelona, Spain
- Hope S. Rugo
- Breast Oncology and Clinical Trials Education, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, USA
- Elzbieta Senkus
- Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland
- George W. Sledge
- Division of Oncology, Stanford School of Medicine, Stanford, USA
- Sandra M. Swain
- Georgetown University Lombardi Comprehensive Cancer Center and MedStar Health, Washington DC, USA
- Christoph Thomssen
- Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale) and Arbeitsgemeinschaft Gynäkologische Onkologie, Kommission Mamma (AGO Guidelines), Germany
- Daniel A. Vorobiof
- Belong.Life, New York, USA
- Peter Vuylsteke
- University of Botswana, Gaborone, Botswana and CHU UCL Namur Hospital, UCLouvain, Belgium
- Theresa Wiseman
- The Royal Marsden NHS Foundation Trust, University of Southampton, United Kingdom and European Oncology Nursing Society (EONS), United Kingdom
- Binghe Xu
- Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
- Alberto Costa
- European School of Oncology, Milan, Italy and Bellinzona, Switzerland
- Larry Norton
- Breast Cancer Programs, Memorial Sloan-Kettering Cancer Centre, New York, USA
- Eric P. Winer
- Yale Cancer Center, Yale University School of Medicine, New Haven, CT, USA
- Journal volume & issue
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Vol. 76
p. 103756
Abstract
This manuscript describes the Advanced Breast Cancer (ABC) international consensus guidelines updated at the last two ABC international consensus conferences (ABC 6 in 2021, virtual, and ABC 7 in 2023, in Lisbon, Portugal), organized by the ABC Global Alliance. It provides the main recommendations on how to best manage patients with advanced breast cancer (inoperable locally advanced or metastatic), of all breast cancer subtypes, as well as palliative and supportive care. These guidelines are based on available evidence or on expert opinion when a higher level of evidence is lacking. Each guideline is accompanied by the level of evidence (LoE), grade of recommendation (GoR) and percentage of consensus reached at the consensus conferences. Updated diagnostic and treatment algorithms are also provided. The guidelines represent the best management options for patients living with ABC globally, assuming accessibility to all available therapies. Their adaptation (i.e. resource-stratified guidelines) is often needed in settings where access to care is limited.
