A Study of Trends in Bacteremia with their Antibiotic Susceptibility in Different Age Groups from a Tertiary Care Hospital of Pune

Abstract

Background: Bloodstream infections are globally a leading cause of morbidity and mortality in all age groups. Aim and Objective: To study the bacteriological profile among different age group patients along with the antibiotic resistance pattern from blood cultures. Material and Methods: This study was conducted on blood culture isolates and their antibiotic resistance from 2018-2019. Identification of organism and antibiotic sensitivity test was performed using standard guidelines. Results: During the two year study, 12,173 blood samples were processed and 1282(10.5%) were culture positive. Of these culture positive, 56.1% were Gram-positive bacteria and 43.9% were Gram-negative isolates. K. pneumoniae was the common isolate from neonates and Coagulase negative Staphylococcus species were the commonest isolates from other age groups. Maximum sensitivity was seen to Linezolid and Vancomycin while maximum resistance to Erythromycin and Ciprofloxacin in Gram positive organisms. Enterobacteriace members except Salmonella spp showed maximum sensitivity to Carbapenem and Chloramphenicol and maximum resistance to Ampicillin and Cephalosporins. Acinetobacter spp and K. pneumoniae showed increased resistance to most drugs over these two years. Conclusion: Early identification of causative agent and antimicrobial sensitivity improves the treatment outcome. Knowing the local changing trend of organism and antibiotic sensitivity pattern helps in rationalizing the use of antibiotics.

Keywords

• bacteremia
• antibiotic resistance trends
• blood culture