Raman microspectroscopy fingerprinting of organoid differentiation state

Kate Tubbesing; Nicholas Moskwa; Ting Chean Khoo; Deirdre A. Nelson; Anna Sharikova; Yunlong Feng; Melinda Larsen; Alexander Khmaladze

doi:10.1186/s11658-022-00347-3

Cellular & Molecular Biology Letters (Jun 2022)

Raman microspectroscopy fingerprinting of organoid differentiation state

Kate Tubbesing,
Nicholas Moskwa,
Ting Chean Khoo,
Deirdre A. Nelson,
Anna Sharikova,
Yunlong Feng,
Melinda Larsen,
Alexander Khmaladze

Affiliations

Kate Tubbesing: Department of Physics, University at Albany, State University of New York
Nicholas Moskwa: Department of Biological Sciences, University at Albany, State University of New York
Ting Chean Khoo: Department of Physics, University at Albany, State University of New York
Deirdre A. Nelson: Department of Biological Sciences, University at Albany, State University of New York
Anna Sharikova: Department of Physics, University at Albany, State University of New York
Yunlong Feng: Department of Mathematics, University at Albany, State University of New York
Melinda Larsen: Department of Biological Sciences, University at Albany, State University of New York
Alexander Khmaladze: Department of Physics, University at Albany, State University of New York

DOI: https://doi.org/10.1186/s11658-022-00347-3
Journal volume & issue: Vol. 27, no. 1
pp. 1 – 20

Abstract

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Highlights Salivary gland organoids have unique Raman signatures detectable with a confocal-based Raman imaging approach. Raman signatures can be detected in unlabeled fixed or live organoids. Raman spectral signatures effectively predict organoid phenotypes.

Published in Cellular & Molecular Biology Letters

ISSN: 1425-8153 (Print); 1689-1392 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General): Cytology
Website: https://cmbl.biomedcentral.com/

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Abstract

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