Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens

Annabelle G. Small; Sarah Harvey; Jaspreet Kaur; Trishni Putty; Alex Quach; Usma Munawara; Khalida Perveen; Andrew McPhee; Charles S. Hii; Antonio Ferrante

doi:10.1038/s42003-021-01943-3

Communications Biology (Mar 2021)

Vitamin D upregulates the macrophage complement receptor immunoglobulin in innate immunity to microbial pathogens

Annabelle G. Small,
Sarah Harvey,
Jaspreet Kaur,
Trishni Putty,
Alex Quach,
Usma Munawara,
Khalida Perveen,
Andrew McPhee,
Charles S. Hii,
Antonio Ferrante

Affiliations

Annabelle G. Small: Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide
Sarah Harvey: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital
Jaspreet Kaur: Department of Immunopathology, SA Pathology, Women’s and Children’s Hospital
Trishni Putty: The Robinson Research Institute and School of Medicine, University of Adelaide
Alex Quach: The Robinson Research Institute and School of Medicine, University of Adelaide
Usma Munawara: The Robinson Research Institute and School of Medicine, University of Adelaide
Khalida Perveen: Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide
Andrew McPhee: Department of Neonatal Medicine, Women’s and Children’s Hospital
Charles S. Hii: The Robinson Research Institute and School of Medicine, University of Adelaide
Antonio Ferrante: Department of Molecular and Cellular Biology, School of Biological Sciences, University of Adelaide

DOI: https://doi.org/10.1038/s42003-021-01943-3
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 7

Abstract

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Annabelle Small et al. report a new role for vitamin D in innate immunity. They find that the vitamin D metabolite 1,25D increases phagocytosis and expression of complement receptor immunoglobulin (CRIg) by macrophages and that treatment of macrophages with a toll like receptor 2 agonist promotes conversion of 25-hydroxyvitamin D3 to 1,25D.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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