Nature Communications (Aug 2018)
Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine
- Efrain A. Ribeiro,
- Marine Salery,
- Joseph R. Scarpa,
- Erin S. Calipari,
- Peter J. Hamilton,
- Stacy M. Ku,
- Hope Kronman,
- Immanuel Purushothaman,
- Barbara Juarez,
- Mitra Heshmati,
- Marie Doyle,
- Casey Lardner,
- Dominicka Burek,
- Ana Strat,
- Stephen Pirpinias,
- Ezekiell Mouzon,
- Ming-Hu Han,
- Rachael L. Neve,
- Rosemary C. Bagot,
- Andrew Kasarskis,
- Ja Wook Koo,
- Eric J. Nestler
Affiliations
- Efrain A. Ribeiro
- Department of Neuroscience, Friedman Brain Institute
- Marine Salery
- Department of Neuroscience, Friedman Brain Institute
- Joseph R. Scarpa
- Department of Genetics and Genomic Science, Icahn Institute of Genomics and Multiscale Biology
- Erin S. Calipari
- Department of Neuroscience, Friedman Brain Institute
- Peter J. Hamilton
- Department of Neuroscience, Friedman Brain Institute
- Stacy M. Ku
- Department of Neuroscience, Friedman Brain Institute
- Hope Kronman
- Department of Neuroscience, Friedman Brain Institute
- Immanuel Purushothaman
- Department of Neuroscience, Friedman Brain Institute
- Barbara Juarez
- Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai
- Mitra Heshmati
- Department of Neuroscience, Friedman Brain Institute
- Marie Doyle
- Department of Neuroscience, Friedman Brain Institute
- Casey Lardner
- Department of Neuroscience, Friedman Brain Institute
- Dominicka Burek
- Department of Neuroscience, Friedman Brain Institute
- Ana Strat
- Department of Neuroscience, Friedman Brain Institute
- Stephen Pirpinias
- Department of Neuroscience, Friedman Brain Institute
- Ezekiell Mouzon
- Department of Neuroscience, Friedman Brain Institute
- Ming-Hu Han
- Department of Neuroscience, Friedman Brain Institute
- Rachael L. Neve
- Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology
- Rosemary C. Bagot
- Department of Neuroscience, Friedman Brain Institute
- Andrew Kasarskis
- Department of Genetics and Genomic Science, Icahn Institute of Genomics and Multiscale Biology
- Ja Wook Koo
- Department of Neuroscience, Friedman Brain Institute
- Eric J. Nestler
- Department of Neuroscience, Friedman Brain Institute
- DOI
- https://doi.org/10.1038/s41467-018-05657-9
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 10
Abstract
While making up a small percentage of neurons in the nucleus accumbens, somatostatin interneurons may have important function in dopamine- and addiction-related behavior. Here, Ribeiro and colleagues show that somatostatin interneurons regulate behavioral responses to cocaine with physiological and transcriptomic changes.
