Mechanisms of antimicrobial peptides as characterized by solid-state NMR

Rong Han; Shenlin Wang

Magnetic Resonance Letters (May 2022)

Mechanisms of antimicrobial peptides as characterized by solid-state NMR

Rong Han,
Shenlin Wang

Affiliations

Rong Han: College of Chemistry and Molecular Engineering and Beijing NMR Center, Peking University, Beijing, 100871, China; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China
Shenlin Wang: College of Chemistry and Molecular Engineering and Beijing NMR Center, Peking University, Beijing, 100871, China; State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China; Beijing National Laboratory for Molecular Science, Beijing, 100871, China; Corresponding author. College of Chemistry and Molecular Engineering and Beijing NMR Center, Peking University, Beijing, 100871, China.

Journal volume & issue: Vol. 2, no. 2
pp. 119 – 129

Abstract

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Antimicrobial peptides (AMP) are small proteins that play critical roles in host defense against microbe invasion. Many AMPs disrupt the cellular membrane of microbe, while the mechanism of action of AMPs can be very sophisticated. Solid-state NMR (SSNMR) technique is powerful in characterizing the mechanism of AMPs in vivo and in vitro. This review summarizes the recent advance of SSNMR technique in AMP mechanisms characterization. We highlight the sample preparation approaches, the SSNMR spectroscopic methods, and a number of outstanding examples of AMP mechanisms elucidated via SSNMR spectroscopy.

Published in Magnetic Resonance Letters

ISSN: 2097-0048 (Print); 2772-5162 (Online)
Publisher: KeAi Communications Co. Ltd.
Country of publisher: China
LCC subjects: Science: Chemistry: Physical and theoretical chemistry; Science: Chemistry: Analytical chemistry
Website: https://www.keaipublishing.com/en/journals/magnetic-resonance-letters/

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