Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis toward hepatocellular carcinoma

• Yun Chen,
• Rui Peng,
• Dongju Feng,
• Changxian Li,
• Yu Jin,
• Boyuan Liu,
• Zewei Zhou,
• Jinying Lu,
• Hua Sun,
• Xiaoxin Mu

Affiliations

Yun Chen

School of Public Health,NHC Key Laboratory of Health Technology Assessment, Key Laboratory of Public Health Safety, Fudan University, Shanghai, China

Rui Peng

OBGYN, Peking University First Hospital, Beijing, China

Dongju Feng

Department of Immunology, Key Laboratory of Immune Microenvironment and Disease, Nanjing Medical University, Nanjing, China

Changxian Li

Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

Yu Jin

Xijing Hospital, Xian, China

Boyuan Liu

Department of Immunology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, China

Zewei Zhou

Department of Immunology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, China

Jinying Lu

Department of Immunology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, China

Hua Sun

Department of Immunology, Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA

Xiaoxin Mu

Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China