Synthesis and Trace-Level Quantification of Mutagenic and Cohort-of-Concern Ciprofloxacin Nitroso Drug Substance-Related Impurities (NDSRIs) and Other Nitroso Impurities Using UPLC-ESI-MS/MSMethod Optimization Using I‑Optimal Mixture Design

• Srinivas Nakka,
• Naresh Kumar Katari,
• Siva Krishna Muchakayala,
• Sreekantha Babu Jonnalagadda,
• Surendra Babu Manabolu Surya

Affiliations

Srinivas Nakka

Department of Chemistry, School of Science, GITAM Deemed to be University, Hyderabad, India

Naresh Kumar Katari

Department of Chemistry, School of Science, GITAM Deemed to be University, Hyderabad, India

Siva Krishna Muchakayala

Department of Chemistry, School of Science, GITAM Deemed to be University, Hyderabad, India

Sreekantha Babu Jonnalagadda

School of Chemistry & Physics, College of Agriculture, Engineering & Science, Westville Campus, University of KwaZulu-Natal, Durban, South Africa

Surendra Babu Manabolu Surya

Department of Chemistry, School of Science, GITAM Deemed to be University, Hyderabad, India