EBioMedicine (Dec 2023)
ENLIGHT: A consensus checklist for reporting laboratory-based studies on the non-visual effects of light in humansResearch in context
- Manuel Spitschan,
- Laura Kervezee,
- Renske Lok,
- Elise McGlashan,
- Raymond P. Najjar,
- Annette E. Allen,
- Marilyne Andersen,
- Salvador Bará,
- Peter Blattner,
- Christine Blume,
- Diane B. Boivin,
- María-Ángeles Bonmatí-Carrión,
- Kai Broszio,
- Timothy M. Brown,
- Sarah Laxhmi Chellappa,
- Jeanne F. Duffy,
- Taisuke Eto,
- Erin Flynn-Evans,
- Steve Fotios,
- Virginie Gabel,
- Corrado Garbazza,
- Gena Glickman,
- Marijke C. Gordijn,
- John P. Hanifin,
- Lauren Hartstein,
- Michael Herf,
- Shigekazu Higuchi,
- Cassie J. Hilditch,
- Kevin W. Houser,
- Anya Hurlbert,
- Monique K. LeBourgeois,
- Steven Lockley,
- Robert Lucas,
- Claudia R.C. Moreno,
- Mirjam Münch,
- Ludovic S. Mure,
- Stuart Peirson,
- Shadab Rahman,
- Victoria L. Revell,
- Roberto G. Rodriguez,
- Kathryn Roecklein,
- A.V. Rukmini,
- John Sammarco,
- Nayantara Santhi,
- Luc J.M. Schlangen,
- Isabel Schöllhorn,
- Katherine M. Sharkey,
- Debra J. Skene,
- Tracey L. Sletten,
- Karin C.H.J. Smolders,
- Oliver Stefani,
- Julia E. Stone,
- Petteri Teikari,
- Michael Terman,
- Khanh Tran Quoc,
- Kazuo Tsubota,
- Ljiljana Udovicic,
- Gilles Vandewalle,
- Jennifer A. Veitch,
- CélineVetter,
- Lisa M. Wu,
- Johannes Zauner,
- Jamie Zeitzer
Affiliations
- Manuel Spitschan
- TUM School of Medicine & Health, Department of Health and Sport Sciences, Technical University of Munich, Munich, Germany; TUM Institute for Advanced Study (TUM-IAS), Technical University of Munich, Garching, Germany; Max Planck Institute for Biological Cybernetics, Max Planck Research Group Translational Sensory & Circadian Neuroscience, Tübingen, Germany; Corresponding author. TUM School of Medicine & Health, Department of Health and Sport Sciences, Technical University of Munich, Munich, Germany.
- Laura Kervezee
- TUMCREATE, Singapore, Singapore; Laboratory for Neurophysiology, Department of Cellular and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands; Corresponding author. Laboratory for Neurophysiology, Department of Cellular and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
- Renske Lok
- Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, USA; Corresponding author. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, USA.
- Elise McGlashan
- Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia; School of Psychological Science and Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia; Corresponding author. Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Victoria, Australia.
- Raymond P. Najjar
- Department of Ophthalmology and Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore; Center for Innovation & Precision Eye Health, National University of Singapore, Singapore, Singapore; Singapore Eye Research Institute, Singapore, Singapore; Ophthalmology and Visual Sciences Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore; Corresponding author. Department of Ophthalmology and Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
- Annette E. Allen
- Marilyne Andersen
- Salvador Bará
- Peter Blattner
- Christine Blume
- Diane B. Boivin
- María-Ángeles Bonmatí-Carrión
- Kai Broszio
- Timothy M. Brown
- Sarah Laxhmi Chellappa
- Jeanne F. Duffy
- Taisuke Eto
- Erin Flynn-Evans
- Steve Fotios
- Virginie Gabel
- Corrado Garbazza
- Gena Glickman
- Marijke C. Gordijn
- John P. Hanifin
- Lauren Hartstein
- Michael Herf
- Shigekazu Higuchi
- Cassie J. Hilditch
- Kevin W. Houser
- Anya Hurlbert
- Monique K. LeBourgeois
- Steven Lockley
- Robert Lucas
- Claudia R.C. Moreno
- Mirjam Münch
- Ludovic S. Mure
- Stuart Peirson
- Shadab Rahman
- Victoria L. Revell
- Roberto G. Rodriguez
- Kathryn Roecklein
- A.V. Rukmini
- John Sammarco
- Nayantara Santhi
- Luc J.M. Schlangen
- Isabel Schöllhorn
- Katherine M. Sharkey
- Debra J. Skene
- Tracey L. Sletten
- Karin C.H.J. Smolders
- Oliver Stefani
- Julia E. Stone
- Petteri Teikari
- Michael Terman
- Khanh Tran Quoc
- Kazuo Tsubota
- Ljiljana Udovicic
- Gilles Vandewalle
- Jennifer A. Veitch
- CélineVetter
- Lisa M. Wu
- Johannes Zauner
- Jamie Zeitzer
- Journal volume & issue
-
Vol. 98
p. 104889
Abstract
Summary: Background: There is no consensus on reporting light characteristics in studies investigating non-visual responses to light. This project aimed to develop a reporting checklist for laboratory-based investigations on the impact of light on non-visual physiology. Methods: A four-step modified Delphi process (three questionnaire-based feedback rounds and one face-to-face group discussion) involving international experts was conducted to reach consensus on the items to be included in the checklist. Following the consensus process, the resulting checklist was tested in a pilot phase with independent experts. Findings: An initial list of 61 items related to reporting light-based interventions was condensed to a final checklist containing 25 items, based upon consensus among experts (final n = 60). Nine items were deemed necessary to report regardless of research question or context. A description of each item is provided in the accompanying Explanation and Elaboration (E&E) document. The independent pilot testing phase led to minor textual clarifications in the checklist and E&E document. Interpretation: The ENLIGHT Checklist is the first consensus-based checklist for documenting and reporting ocular light-based interventions for human studies. The implementation of the checklist will enhance the impact of light-based research by ensuring comprehensive documentation, enhancing reproducibility, and enabling data aggregation across studies. Funding: Network of European Institutes for Advanced Study (NETIAS) Constructive Advanced Thinking (CAT) programme; Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust, 204686/Z/16/Z); Netherlands Organisation for Health Research and Development VENI fellowship (2020–09150161910128); U.S. Department of Defense Grant (W81XWH-16-1-0223); National University of Singapore (NUHSRO/2022/038/Startup/08); and National Research Foundation Singapore (NRF2022-THE004-0002).
