Evaluating the dynamics of hospital COVID-19 contacts and subsequent conversion to SARS-CoV-2 infection: a multi-centre retrospective cohort study

Nneoma Okeke; Luke B. Snell; Balram Rathish; Amal Hussein; William Newsholme; Damien Mack; Aodhan Breathnach; Jonathan A. Otter

Infection Prevention in Practice (Jun 2024)

Evaluating the dynamics of hospital COVID-19 contacts and subsequent conversion to SARS-CoV-2 infection: a multi-centre retrospective cohort study

Nneoma Okeke,
Luke B. Snell,
Balram Rathish,
Amal Hussein,
William Newsholme,
Damien Mack,
Aodhan Breathnach,
Jonathan A. Otter

Affiliations

Nneoma Okeke: Directorate of Infection, Guy's and St. Thomas NHS Foundation Trust, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK; Corresponding author.
Luke B. Snell: Directorate of Infection, Guy's and St. Thomas NHS Foundation Trust, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK
Balram Rathish: Directorate of Infection, Guy's and St. Thomas NHS Foundation Trust, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK
Amal Hussein: Directorate of Infection, Guy's and St. Thomas NHS Foundation Trust, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK
William Newsholme: Directorate of Infection, Guy's and St. Thomas NHS Foundation Trust, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK
Damien Mack: Department of Microbiology, Royal Free Hospital, Royal Free London NHS Foundation Trust, Pond Street NW3 2QG, UK
Aodhan Breathnach: Department of Infection, St George's University Hospitals NHS Foundation Trust, Tooting, London SW17 0QT, UK
Jonathan A. Otter: Directorate of Infection, Guy's and St. Thomas NHS Foundation Trust, St. Thomas' Hospital, Lambeth Palace Road, London, SE1 7EH, UK; National Institute for Healthcare Research Health Protection Research Unit (NIHR HPRU) in HCAI and AMR, Imperial College London & Public Health England, Hammersmith Hospital, Du Cane Road, W12 0HS, UK

Journal volume & issue: Vol. 6, no. 2
p. 100325

Abstract

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Summary: We investigated the dynamics of COVID-19 contacts subsequent conversion to SARS-CoV-2 infection in an inpatient setting across three National Health Service (NHS) Trusts. 9.2% (476/5,156) COVID-19 contacts met inclusion criteria, were typable and tested positive for COVID-19. There was no significant difference between Omicron and non-Omicron contacts overall conversion proportions. Omicron contacts converted faster than non-Omicron contacts (median 3 days vs 4 days, P=0.03), and had significantly greater proportions of early conversions at day 3, 5, and 7 timepoints.

Published in Infection Prevention in Practice

ISSN: 2590-0889 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/infection-prevention-in-practice

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