Cell reprogramming shapes the mitochondrial DNA landscape

Wei Wei; Daniel J. Gaffney; Patrick F. Chinnery

doi:10.1038/s41467-021-25482-x

Nature Communications (Sep 2021)

Cell reprogramming shapes the mitochondrial DNA landscape

Wei Wei,
Daniel J. Gaffney,
Patrick F. Chinnery

Affiliations

Wei Wei: Department of Clinical Neuroscience, University of Cambridge
Daniel J. Gaffney: Human Induced Pluripotent Stem Cell Initiative, Wellcome Genome Campus
Patrick F. Chinnery: Department of Clinical Neuroscience, University of Cambridge

DOI: https://doi.org/10.1038/s41467-021-25482-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Here the authors describe high depth mitochondrial DNA (mtDNA) sequence analysis of 146 human induced pluripotent stem cell (hiPSC) lines as well as single cell RNA-seq (scRNAseq) of hiPSCs undergoing differentiation from 125 donors; reporting mtDNA diversity and some variants favoured after reprogramming.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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