Acta Medica Medianae (Jul 2004)
THE INFLUENCE OF ASCORBIC ACID ON DEVELOPMENT OF ADENOCARCINOMA MAMMAE IN MICES
Abstract
The influence of great dosage of ascorbic acid during the experimental induction of adenocarcinoma mammae was experimented. For the experiments the female of CBA/H mice were used. The animals were divided into two groups: the control (K) and experimental (I, II, III) group. The mice of the control group were given 0.5 ml physiological solution, and the mice of experimental subgroup I were given 10, and of the subgroup II were given 100, and of subgroup III were given 1.000 mg of ascorbic acid/d. In the beginning of experiment all animals of both control and experimental group were given 5x10 6 of live cells of adenocarcinoma mammae. During and in the end of the experiment the changes in the body weight, weigth of adenocarcinoma mammae, and weigth o spleen was examined. The achieved results exemplify that the aplication of high doses of ascorbic acid, in the case of CBA/H mice, decreased the weight of mice, decreased the weight of adenocacinoma mammae, decreased the mass and celularity of spleen, and decreased stimulates the number of leucocytes.
