The value of urinary gonadotropins in the diagnosis of central precocious puberty: a meta-analysis

Abstract

Abstract Background The gonadotropin-releasing hormone (GnRH) stimulation test is time-consuming, invasive, and costly. However, it is the diagnostic gold standard for central precocious puberty (CPP), which in girls is defined as the onset of secondary sexual characteristics before the age of 8 years accompanied by breast buds, accelerated growth, and advanced bone age. This meta-analysis was performed to compare the diagnostic value of urinary gonadotropins and the GnRH stimulation test for CPP. Methods We searched six databases for relevant literature. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we estimated the sensitivity, specificity, area under the summary receiver operating characteristic curve (AUC), and publication bias. Results Six eligible trials fulfilled the inclusion criteria. In the meta-analysis of urinary luteinizing hormone (ULH), after excluding the data of one study, we obtained an AUC of 0.90 (sensitivity = 0.81, specificity = 0.85). The meta-analysis of the ULH to urinary follicle-stimulating hormone (UFSH) ratio revealed an AUC of 0.8116 (sensitivity = 0.79, specificity = 0.84). Conclusion Both the ULH level and ULH:UFSH ratio are effective and available approaches for CPP diagnosis. Trial Registration INPLASY 2021120076 .

Keywords

• Urinary gonadotropins
• Luteinizing hormone
• Follicle-stimulating hormone
• Gonadotropin-releasing hormone stimulation test
• Central precocious puberty