Nature Communications (Apr 2022)
Immunosuppressive niche engineering at the onset of human colorectal cancer
- Chandler D. Gatenbee,
- Ann-Marie Baker,
- Ryan O. Schenck,
- Maximilian Strobl,
- Jeffrey West,
- Margarida P. Neves,
- Sara Yakub Hasan,
- Eszter Lakatos,
- Pierre Martinez,
- William C. H. Cross,
- Marnix Jansen,
- Manuel Rodriguez-Justo,
- Christopher J. Whelan,
- Andrea Sottoriva,
- Simon Leedham,
- Mark Robertson-Tessi,
- Trevor A. Graham,
- Alexander R. A. Anderson
Affiliations
- Chandler D. Gatenbee
- Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute
- Ann-Marie Baker
- Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London
- Ryan O. Schenck
- Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute
- Maximilian Strobl
- Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute
- Jeffrey West
- Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute
- Margarida P. Neves
- Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London
- Sara Yakub Hasan
- Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London
- Eszter Lakatos
- Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London
- Pierre Martinez
- Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London
- William C. H. Cross
- Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London
- Marnix Jansen
- Department of Pathology, University College London Hospital
- Manuel Rodriguez-Justo
- Department of Pathology, University College London Hospital
- Christopher J. Whelan
- Cancer Physiology, H. Lee Moffitt Cancer Center & Research Institute
- Andrea Sottoriva
- Center for Evolution and Cancer, Institute of Cancer Research
- Simon Leedham
- Wellcome Centre for Human Genetics, University of Oxford
- Mark Robertson-Tessi
- Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute
- Trevor A. Graham
- Evolution and Cancer Laboratory, Centre for Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London
- Alexander R. A. Anderson
- Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute
- DOI
- https://doi.org/10.1038/s41467-022-29027-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Integration of mathematical modeling, ecological analyses of patient biopsies, and neoantigen heterogeneity suggests recruitment of immunosuppressive cells is key to initializing transformation from adenoma to carcinoma in human colorectal cancer.
