Expression and value of Survivin and NKTs in cervical cancer

Abstract

Objective To investigate the expression of Survivin and level of natural killer T cells（NKTs） in patients with cervical cancer and its clinical significance. Methods A total of 152 cervical cancer patients admitted to the NO.2 Hospital of Baoding from January 2021 to March 2022 were selected as cervical cancer group, and 80 healthy subjects received physical examination during the same period were selected as healthy group. The expression levels of NKTs, Survivin, carcinoembryonic antigen（CEA）, carbohydrate antigen 125（CA125）, vascular endothelial growth factor（VEGF）, and interleukin-12（IL-12） were compared between two groups. The ROC curve was used to analyze the efficacy of various serum indicators in the diagnosis of cervical cancer. Results Compared with healthy group, serum levels of NKTs, CEA, CA125 and VEGF were significantly increased, while IL-12 was significantly decreased in cervical cancer group（P<0.01）. Compared with stage Ⅰ-Ⅱ cervical cancer, the levels of Survivin and serum CEA, CA125, VEGF were higher, while the levels of NKTs, IL-12 were lower in stage Ⅲ-Ⅳ（P<0.01）. The combined of serum indicators had the highest efficiency in the diagnosis of cervical cancer (AUC=0.996, sensitivity=92.00%, specificity=96.00%). There was a negative correlation between NKTs and Survivin expression in cervical cancer patients (r=-0.657, P<0.01). Conclusion The higher the clinicopathological stage of cervical cancer patients, the higher the expression of Survivin in the cancer tissue, and the lower the serum NKTs level. Cervical cancer can be jointly detected with serum NKTs, CEA, CA125, VEGF, and IL-12.

Keywords

• natural killer t cells
• survivin
• cervical cancer
• carcinoembryonic antigen
• carbohydrate antigen 125
• vascular endothelial growth factor
• interleukin-12