mSphere (Feb 2021)

Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase

  • Ericka Kirkpatrick Roubidoux,
  • Meagan McMahon,
  • Juan Manuel Carreño,
  • Christina Capuano,
  • Kaijun Jiang,
  • Viviana Simon,
  • Harm van Bakel,
  • Patrick Wilson,
  • Florian Krammer

DOI
https://doi.org/10.1128/mSphere.00958-20
Journal volume & issue
Vol. 6, no. 1

Abstract

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The influenza virus neuraminidase is an emerging target for universal influenza virus vaccines. However, in contrast to influenza virus hemagglutinin, we know little about antibody epitopes and antigenic sites on the neuraminidase. Characterizing and defining these sites is aiding vaccine development and helping to understand antigenic drift of NA.