Nature Communications (Sep 2021)

Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes

  • Hiroki Sugishita,
  • Takashi Kondo,
  • Shinsuke Ito,
  • Manabu Nakayama,
  • Nayuta Yakushiji-Kaminatsui,
  • Eiryo Kawakami,
  • Yoko Koseki,
  • Yasuhide Ohinata,
  • Jafar Sharif,
  • Mio Harachi,
  • Neil P. Blackledge,
  • Robert J. Klose,
  • Haruhiko Koseki

DOI
https://doi.org/10.1038/s41467-021-24894-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Polycomb repressive complexes (PRC1 and PRC2) repress genes that are crucial for development via epigenetic modifications; however, their role in differentiation is not well known. Here the authors reveal that a PCGF1-containing PRC1 variant facilitates exit from pluripotency by downregulating target genes and recruiting PRC2.