Nature Communications (Mar 2017)
The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction
- Guang Yang,
- Xinyu Weng,
- Yuhao Zhao,
- Xinjian Zhang,
- Yuanping Hu,
- Xin Dai,
- Peng Liang,
- Peng Wang,
- LeiLei Ma,
- Xiaolei Sun,
- Lei Hou,
- Huihui Xu,
- Mingming Fang,
- Yuehua Li,
- Thomas Jenuwein,
- Yong Xu,
- Aijun Sun
Affiliations
- Guang Yang
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Xinyu Weng
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Yuhao Zhao
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Xinjian Zhang
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Yuanping Hu
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Xin Dai
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Peng Liang
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Peng Wang
- Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University
- LeiLei Ma
- Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University
- Xiaolei Sun
- Institute of Biomedical Sciences, Fudan University
- Lei Hou
- Institute of Biomedical Sciences, Fudan University
- Huihui Xu
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Mingming Fang
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Yuehua Li
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Thomas Jenuwein
- Department of Epigenetics, Max Planck Institute of Immunobiology and Epigenetics
- Yong Xu
- Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention and Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University
- Aijun Sun
- Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University
- DOI
- https://doi.org/10.1038/ncomms14941
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of SUV39H in mice is cardioprotective.
