Nature Communications (Nov 2020)
Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
- Flavia Chiuppesi,
- Marcela d’Alincourt Salazar,
- Heidi Contreras,
- Vu H. Nguyen,
- Joy Martinez,
- Yoonsuh Park,
- Jenny Nguyen,
- Mindy Kha,
- Angelina Iniguez,
- Qiao Zhou,
- Teodora Kaltcheva,
- Roman Levytskyy,
- Nancy D. Ebelt,
- Tae Hyuk Kang,
- Xiwei Wu,
- Thomas F. Rogers,
- Edwin R. Manuel,
- Yuriy Shostak,
- Don J. Diamond,
- Felix Wussow
Affiliations
- Flavia Chiuppesi
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Marcela d’Alincourt Salazar
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Heidi Contreras
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Vu H. Nguyen
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Joy Martinez
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Yoonsuh Park
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Jenny Nguyen
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Mindy Kha
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Angelina Iniguez
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Qiao Zhou
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Teodora Kaltcheva
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Roman Levytskyy
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Nancy D. Ebelt
- Department of Immuno-Oncology, Beckman Research Institute of the City of Hope
- Tae Hyuk Kang
- Integrative Genomics Core, Beckman Research Institute of the City of Hope
- Xiwei Wu
- Integrative Genomics Core, Beckman Research Institute of the City of Hope
- Thomas F. Rogers
- Division of Infectious Diseases and Global Public Health, University of California San Diego, School of Medicine
- Edwin R. Manuel
- Department of Immuno-Oncology, Beckman Research Institute of the City of Hope
- Yuriy Shostak
- Research Business Development, City of Hope
- Don J. Diamond
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- Felix Wussow
- Department of Hematology and Transplant Center, City of Hope National Medical Center
- DOI
- https://doi.org/10.1038/s41467-020-19819-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Chiuppesi et al. demonstrate the use of a synthetic poxvirus-based platform to rapidly generate multi-antigenic vaccine candidates expressing spike and nucleocapsid antigens of SARS-CoV-2. Immunization of mice stimulates potent antigen-specific humoral and cellular immune responses, including neutralizing antibodies.
