International Journal of General Medicine (Jan 2021)
ROHHAD (Rapid-onset Obesity with Hypoventilation, Hypothalamic Dysfunction, Autonomic Dysregulation) Syndrome—What Every Pediatrician Should Know About the Etiopathogenesis, Diagnosis and Treatment: A Review
Abstract
Cecilia Lazea,1 Lucia Sur,1 Mira Florea2 1Department Pediatrics I, Emergency Pediatric Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, Romania; 2Community Medicine Department, University of Medicine and Pharmacy “Iuliu Hatieganu”, Cluj-Napoca, RomaniaCorrespondence: Cecilia LazeaDepartment Pediatrics I, Emergency Pediatric Hospital, University of Medicine and Pharmacy “Iuliu Hatieganu”, 68, Motilor Street, Cluj-Napoca 400370, RomaniaTel +40744353764Fax +40264402539Email [email protected]: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, autonomic dysregulation (ROHHAD) syndrome is a rare disease with unknown and debated etiology, characterized by precipitous obesity in young children, hypoventilation and autonomic dysregulation with various endocrine abnormalities. Neuroendocrine tumors can be associated in more than half of the cases. This rare condition has a severe outcome because of high morbidity and mortality. We provide a comprehensive description of the etiopathogenetic theories of the disease, clinical presentation, diagnostic workup and treatment possibilities.Keywords: obesity, hypoventilation, hypothalamic dysfunction, autonomic dysregulation
