Metal-responsive promoter DNA compaction by the ferric uptake regulator

Davide Roncarati; Simone Pelliciari; Nicola Doniselli; Stefano Maggi; Andrea Vannini; Luca Valzania; Luca Mazzei; Barbara Zambelli; Claudio Rivetti; Alberto Danielli

doi:10.1038/ncomms12593

Nature Communications (Aug 2016)

Metal-responsive promoter DNA compaction by the ferric uptake regulator

Davide Roncarati,
Simone Pelliciari,
Nicola Doniselli,
Stefano Maggi,
Andrea Vannini,
Luca Valzania,
Luca Mazzei,
Barbara Zambelli,
Claudio Rivetti,
Alberto Danielli

Affiliations

Davide Roncarati: Department of Pharmacy and Biotechnology (FaBiT), University of Bologna
Simone Pelliciari: Department of Pharmacy and Biotechnology (FaBiT), University of Bologna
Nicola Doniselli: Department of Life Sciences, University of Parma
Stefano Maggi: Department of Life Sciences, University of Parma
Andrea Vannini: Department of Pharmacy and Biotechnology (FaBiT), University of Bologna
Luca Valzania: Department of Pharmacy and Biotechnology (FaBiT), University of Bologna
Luca Mazzei: Department of Pharmacy and Biotechnology (FaBiT), University of Bologna
Barbara Zambelli: Department of Pharmacy and Biotechnology (FaBiT), University of Bologna
Claudio Rivetti: Department of Life Sciences, University of Parma
Alberto Danielli: Department of Pharmacy and Biotechnology (FaBiT), University of Bologna

DOI: https://doi.org/10.1038/ncomms12593
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The Fur protein regulates transcription of bacterial genes in response to metal ions. Here, the authors show that the Fur protein from Helicobacter pylorirepresses transcription by iron-responsive oligomerization and DNA compaction, encasing the transcriptional start site in a macromolecular complex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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