Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy

Cheng-Tao Jiang; Kai-Ge Chen; An Liu; Hua Huang; Ya-Nan Fan; Dong-Kun Zhao; Qian-Ni Ye; Hou-Bing Zhang; Cong-Fei Xu; Song Shen; Meng-Hua Xiong; Jin-Zhi Du; Xian-Zhu Yang; Jun Wang

doi:10.1038/s41467-021-21497-6

Nature Communications (Mar 2021)

Immunomodulating nano-adaptors potentiate antibody-based cancer immunotherapy

Cheng-Tao Jiang,
Kai-Ge Chen,
An Liu,
Hua Huang,
Ya-Nan Fan,
Dong-Kun Zhao,
Qian-Ni Ye,
Hou-Bing Zhang,
Cong-Fei Xu,
Song Shen,
Meng-Hua Xiong,
Jin-Zhi Du,
Xian-Zhu Yang,
Jun Wang

Affiliations

Cheng-Tao Jiang: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Kai-Ge Chen: School of Life Sciences, University of Science and Technology of China
An Liu: School of Life Sciences, University of Science and Technology of China
Hua Huang: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Ya-Nan Fan: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Dong-Kun Zhao: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Qian-Ni Ye: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Hou-Bing Zhang: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Cong-Fei Xu: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Song Shen: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Meng-Hua Xiong: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Jin-Zhi Du: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Xian-Zhu Yang: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus
Jun Wang: School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus

DOI: https://doi.org/10.1038/s41467-021-21497-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Current strategies to boost anti-tumor immune response include the use of immune checkpoint inhibitors and bispecific T cell-engaging antibodies. Here the authors describe a versatile antibody immobilization nanoplatform that can be used to deliver different combinations of immunotherapeutics, showing therapeutic superiority in pre-clinical models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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