Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease

Konstantinos Poulakis; Joana B. Pereira; J.-Sebastian Muehlboeck; Lars-Olof Wahlund; Örjan Smedby; Giovanni Volpe; Colin L. Masters; David Ames; Yoshiki Niimi; Takeshi Iwatsubo; Daniel Ferreira; Eric Westman; Japanese Alzheimer’s Disease Neuroimaging Initiative; Australian Imaging, Biomarkers and Lifestyle study

doi:10.1038/s41467-022-32202-6

Nature Communications (Aug 2022)

Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer’s disease

Konstantinos Poulakis,
Joana B. Pereira,
J.-Sebastian Muehlboeck,
Lars-Olof Wahlund,
Örjan Smedby,
Giovanni Volpe,
Colin L. Masters,
David Ames,
Yoshiki Niimi,
Takeshi Iwatsubo,
Daniel Ferreira,
Eric Westman,
Japanese Alzheimer’s Disease Neuroimaging Initiative,
Australian Imaging, Biomarkers and Lifestyle study

Affiliations

Konstantinos Poulakis: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet
Joana B. Pereira: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet
J.-Sebastian Muehlboeck: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet
Lars-Olof Wahlund: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet
Örjan Smedby: Department of Biomedical Engineering and Health Systems (MTH), KTH Royal Institute of Technology
Giovanni Volpe: Department of Physics, University of Gothenburg
Colin L. Masters: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne
David Ames: Academic Unit for Psychiatry of Old Age, St George’s Hospital, University of Melbourne
Yoshiki Niimi: Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital
Takeshi Iwatsubo: Unit for Early and Exploratory Clinical Development, The University of Tokyo Hospital
Daniel Ferreira: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet
Eric Westman: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet
Japanese Alzheimer’s Disease Neuroimaging Initiative
Australian Imaging, Biomarkers and Lifestyle study

DOI: https://doi.org/10.1038/s41467-022-32202-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Different types of atrophy in Alzheimer’s disease may reflect different disease stages or biologically distinct subtypes. Here the authors use longitudinal neuroimaging data to demonstrate five distinct patterns of atrophy with different demographical and cognitive characteristics.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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